Drug interactions
Frovatriptan + Lisdexamfetamine
Severity: Moderate
Frovatriptan and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance serotonin and norepinephrine signaling, and frovatriptan is a serotonin receptor agonist. The combination may cause additive serotonergic effects and higher blood pressure.
What this interaction means in plain words
Frovatriptan and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic and pressor effects.
What to do
Counsel on symptoms of serotonin syndrome and monitor blood pressure. Stop one agent if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Frovatriptan and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance serotonin and norepinephrine signaling, and frovatriptan is a serotonin receptor agonist. The combination may cause additive serotonergic effects and higher blood pressure.
How serious is the interaction between Frovatriptan and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms of serotonin syndrome and monitor blood pressure. Stop one agent if toxicity occurs.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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