Drug interactions
Fruquintinib + Modafinil
Severity: Minor
Fruquintinib and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil weakly to moderately induces CYP3A4 and fruquintinib is partly cleared by CYP3A4. Exposure to fruquintinib may fall, but the effect is expected to be small.
What this interaction means in plain words
Fruquintinib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fruquintinib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, modestly increasing fruquintinib metabolism.
What to do
Continue fruquintinib at the recommended dose and monitor for treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Fruquintinib
- Amobarbital + Fruquintinib Major
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Bosentan + Fruquintinib Moderate
Frequently asked questions
Can I take Fruquintinib with Modafinil?
MediHelp rates the interaction as minor. Fruquintinib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil weakly to moderately induces CYP3A4 and fruquintinib is partly cleared by CYP3A4. Exposure to fruquintinib may fall, but the effect is expected to be small.
How serious is the interaction between Fruquintinib and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue fruquintinib at the recommended dose and monitor for treatment response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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