Drug interactions
Furosemide + Imidapril
Severity: Moderate
Furosemide and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining imidapril with furosemide can cause marked hypotension and acute renal impairment, particularly at initiation in volume-depleted patients. The combination is usable when started carefully.
What this interaction means in plain words
Furosemide and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Imidapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of diuretic-induced volume depletion and ACE inhibition lowering glomerular filtration pressure.
What to do
Begin imidapril at a low dose and consider reducing the furosemide dose beforehand. Monitor blood pressure, creatinine and potassium shortly after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Furosemide with Imidapril?
MediHelp rates the interaction as moderate. Furosemide and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining imidapril with furosemide can cause marked hypotension and acute renal impairment, particularly at initiation in volume-depleted patients. The combination is usable when started carefully.
How serious is the interaction between Furosemide and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin imidapril at a low dose and consider reducing the furosemide dose beforehand. Monitor blood pressure, creatinine and potassium shortly after initiation.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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