Drug interactions
Furosemide + Lornoxicam
Severity: Moderate
Furosemide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can reduce furosemide's diuretic and antihypertensive effect and, with a diuretic, raise the risk of acute kidney injury, especially with dehydration. Fluid retention and heart failure worsening are also possible.
What this interaction means in plain words
Furosemide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing loop diuretic action.
What to do
Avoid prolonged combined use where possible; use the lowest NSAID dose for the shortest time. Monitor renal function, blood pressure, weight and diuretic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Furosemide with Lornoxicam?
MediHelp rates the interaction as moderate. Furosemide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can reduce furosemide's diuretic and antihypertensive effect and, with a diuretic, raise the risk of acute kidney injury, especially with dehydration. Fluid retention and heart failure worsening are also possible.
How serious is the interaction between Furosemide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged combined use where possible; use the lowest NSAID dose for the shortest time. Monitor renal function, blood pressure, weight and diuretic response.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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