Drug interactions
Furosemide + Losartan
Severity: Moderate
Furosemide and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide-induced volume depletion may cause an exaggerated hypotensive response and renal function decline when losartan is added. Potassium effects partly counteract each other.
What this interaction means in plain words
Furosemide and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of volume depletion and angiotensin receptor blockade; opposing potassium effects.
What to do
Monitor blood pressure, creatinine and potassium after starting or adjusting therapy. Consider lowering the furosemide dose if volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Furosemide with Losartan?
MediHelp rates the interaction as moderate. Furosemide and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide-induced volume depletion may cause an exaggerated hypotensive response and renal function decline when losartan is added. Potassium effects partly counteract each other.
How serious is the interaction between Furosemide and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or adjusting therapy. Consider lowering the furosemide dose if volume depleted.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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