Drug interactions
Furosemide + Magnesium oxide
Severity: Minor
Furosemide and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide increases urinary magnesium excretion and can cause hypomagnesemia during long-term use. Magnesium oxide supplements may be needed to offset this loss, and their effect may be partly counteracted.
What this interaction means in plain words
Furosemide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Inhibition of the Na-K-2Cl cotransporter in the thick ascending limb reduces paracellular magnesium reabsorption, increasing renal loss.
What to do
Monitor serum magnesium and potassium during long-term furosemide therapy and adjust the magnesium dose to the measured level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Furosemide with Magnesium oxide?
MediHelp rates the interaction as minor. Furosemide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide increases urinary magnesium excretion and can cause hypomagnesemia during long-term use. Magnesium oxide supplements may be needed to offset this loss, and their effect may be partly counteracted.
How serious is the interaction between Furosemide and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during long-term furosemide therapy and adjust the magnesium dose to the measured level.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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