Drug interactions
Furosemide + Nabumetone
Severity: Moderate
Furosemide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics and may cause sodium retention. In volume-depleted or at-risk patients the combination can also increase the risk of acute kidney injury.
What this interaction means in plain words
Furosemide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit prostaglandin synthesis, reducing renal blood flow and prostaglandin-dependent natriuresis, which opposes furosemide action.
What to do
Monitor diuretic response, weight, blood pressure and renal function, especially at the start of therapy. Increase the furosemide dose if needed or use an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Nabumetone?
MediHelp rates the interaction as moderate. Furosemide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics and may cause sodium retention. In volume-depleted or at-risk patients the combination can also increase the risk of acute kidney injury.
How serious is the interaction between Furosemide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure and renal function, especially at the start of therapy. Increase the furosemide dose if needed or use an alternative analgesic.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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