Drug interactions
Gabapentin enacarbil + Loratadine
Severity: Minor
Gabapentin enacarbil and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which causes somnolence and dizziness and can contribute to respiratory depression with other CNS depressants. Loratadine is minimally sedating, so the added effect is usually small.
What this interaction means in plain words
Gabapentin enacarbil and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin enacarbil belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor for sedation and dizziness, especially after dose changes. Use the lowest effective doses, with extra care in the elderly or those with respiratory disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Loratadine?
MediHelp rates the interaction as minor. Gabapentin enacarbil and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin enacarbil is converted to gabapentin, which causes somnolence and dizziness and can contribute to respiratory depression with other CNS depressants. Loratadine is minimally sedating, so the added effect is usually small.
How serious is the interaction between Gabapentin enacarbil and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, especially after dose changes. Use the lowest effective doses, with extra care in the elderly or those with respiratory disease.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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