Drug interactions
Gabapentin enacarbil + Oxycodone
Severity: Major
Gabapentin enacarbil and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids combined with opioids increase the risk of sedation and respiratory depression. Serious or fatal respiratory depression has been reported, especially in older patients or those with lung disease.
What this interaction means in plain words
Gabapentin enacarbil and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gabapentin enacarbil belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from gabapentinoid activity and opioid agonism.
What to do
Use the lowest effective doses of each drug and monitor for sedation and respiratory depression. Take extra care in older patients and those with respiratory impairment or renal dysfunction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Oxycodone?
MediHelp rates the interaction as major. Gabapentin enacarbil and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentinoids combined with opioids increase the risk of sedation and respiratory depression. Serious or fatal respiratory depression has been reported, especially in older patients or those with lung disease.
How serious is the interaction between Gabapentin enacarbil and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of each drug and monitor for sedation and respiratory depression. Take extra care in older patients and those with respiratory impairment or renal dysfunction.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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