Drug interactions
Gabapentin enacarbil + Trimipramine
Severity: Moderate
Gabapentin enacarbil and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause marked sedation and, rarely, respiratory depression. Risk is higher in older adults, in those with lung disease and with other depressants.
What this interaction means in plain words
Gabapentin enacarbil and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation or dose increases. Avoid additional sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Trimipramine?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause marked sedation and, rarely, respiratory depression. Risk is higher in older adults, in those with lung disease and with other depressants.
How serious is the interaction between Gabapentin enacarbil and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation or dose increases. Avoid additional sedatives where possible.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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