Drug interactions
Gabapentin enacarbil + Vortioxetine
Severity: Minor
Gabapentin enacarbil and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil causes somnolence and dizziness, and additional CNS-active drugs may increase sedation. Vortioxetine is not a classic CNS depressant, so significant respiratory depression is unlikely.
What this interaction means in plain words
Gabapentin enacarbil and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin enacarbil belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS effects; gabapentinoid sedation with serotonergic antidepressant side effects.
What to do
Monitor for excess sedation and dizziness when starting or increasing either drug. Caution patients about driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Vortioxetine?
MediHelp rates the interaction as minor. Gabapentin enacarbil and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin enacarbil causes somnolence and dizziness, and additional CNS-active drugs may increase sedation. Vortioxetine is not a classic CNS depressant, so significant respiratory depression is unlikely.
How serious is the interaction between Gabapentin enacarbil and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness when starting or increasing either drug. Caution patients about driving.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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