Drug interactions
Galantamine + Posaconazole
Severity: Minor
Galantamine and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase galantamine concentrations because galantamine is metabolised partly by CYP3A4 and CYP2D6. This could increase cholinergic effects such as nausea, vomiting, bradycardia and syncope.
What this interaction means in plain words
Galantamine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces galantamine clearance.
What to do
No routine dose change; monitor heart rate and gastrointestinal tolerability, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Posaconazole?
MediHelp rates the interaction as minor. Galantamine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase galantamine concentrations because galantamine is metabolised partly by CYP3A4 and CYP2D6. This could increase cholinergic effects such as nausea, vomiting, bradycardia and syncope.
How serious is the interaction between Galantamine and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor heart rate and gastrointestinal tolerability, particularly in older patients.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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