Drug interactions
Ganaxolone + Propofol
Severity: Moderate
Ganaxolone and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence, and it adds to the sedative effect of propofol. Excess sedation and respiratory depression are possible.
What this interaction means in plain words
Ganaxolone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Titrate propofol cautiously with reduced doses and monitor sedation depth and respiratory function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Propofol?
MediHelp rates the interaction as moderate. Ganaxolone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence, and it adds to the sedative effect of propofol. Excess sedation and respiratory depression are possible.
How serious is the interaction between Ganaxolone and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously with reduced doses and monitor sedation depth and respiratory function.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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