Drug interactions
Gefitinib + Nevirapine
Severity: Moderate
Gefitinib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower gefitinib concentrations through CYP3A4 induction, potentially reducing antitumor efficacy. Gefitinib labeling advises a dose increase with strong inducers.
What this interaction means in plain words
Gefitinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing gefitinib metabolism.
What to do
Monitor tumor response and tolerability. Consider a gefitinib dose increase as per labeling for strong inducers, and return to the standard dose after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Nevirapine?
MediHelp rates the interaction as moderate. Gefitinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower gefitinib concentrations through CYP3A4 induction, potentially reducing antitumor efficacy. Gefitinib labeling advises a dose increase with strong inducers.
How serious is the interaction between Gefitinib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and tolerability. Consider a gefitinib dose increase as per labeling for strong inducers, and return to the standard dose after the inducer is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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