Drug interactions
Gemcitabine + Trastuzumab deruxtecan
Severity: Moderate
Gemcitabine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, and combining them may increase the frequency and severity of neutropenia and febrile neutropenia, raising infection risk.
What this interaction means in plain words
Gemcitabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemcitabine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from gemcitabine and the topoisomerase I inhibitor payload.
What to do
Monitor complete blood counts closely and modify doses per neutropenia guidance. Consider growth factor support and evaluate fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Gemcitabine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Gemcitabine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, and combining them may increase the frequency and severity of neutropenia and febrile neutropenia, raising infection risk.
How serious is the interaction between Gemcitabine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and modify doses per neutropenia guidance. Consider growth factor support and evaluate fever promptly.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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