Drug interactions
Gemfibrozil + Paclitaxel
Severity: Moderate
Gemfibrozil and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil is a strong CYP2C8 inhibitor and paclitaxel is metabolized mainly by CYP2C8 (with CYP3A4). Co-administration may raise paclitaxel exposure and increase toxicity such as neutropenia and neuropathy. The magnitude in patients is not well quantified.
What this interaction means in plain words
Gemfibrozil and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Gemfibrozil and its glucuronide inhibit CYP2C8, reducing paclitaxel metabolism.
What to do
Prefer an alternative lipid-lowering agent during paclitaxel therapy if possible. If combined, monitor blood counts and neuropathy and consider paclitaxel dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Gemfibrozil with Paclitaxel?
MediHelp rates the interaction as moderate. Gemfibrozil and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil is a strong CYP2C8 inhibitor and paclitaxel is metabolized mainly by CYP2C8 (with CYP3A4). Co-administration may raise paclitaxel exposure and increase toxicity such as neutropenia and neuropathy. The magnitude in patients is not well quantified.
How serious is the interaction between Gemfibrozil and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative lipid-lowering agent during paclitaxel therapy if possible. If combined, monitor blood counts and neuropathy and consider paclitaxel dose reduction.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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