Drug interactions
Gemfibrozil + Pexidartinib
Severity: Moderate
Gemfibrozil and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is cleared by CYP3A4 and UGT1A4, and gemfibrozil can inhibit glucuronidation. Increased pexidartinib exposure may raise the risk of hepatotoxicity, which is a serious toxicity of this drug.
What this interaction means in plain words
Gemfibrozil and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Pexidartinib belongs to Oncology.
Why it happens
Gemfibrozil may inhibit UGT-mediated glucuronidation of pexidartinib, although the specific enzyme contribution is not well established.
What to do
Monitor liver enzymes and bilirubin closely. Reduce the pexidartinib dose according to labeling if a UGT inhibitor is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Gemfibrozil with Pexidartinib?
MediHelp rates the interaction as moderate. Gemfibrozil and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is cleared by CYP3A4 and UGT1A4, and gemfibrozil can inhibit glucuronidation. Increased pexidartinib exposure may raise the risk of hepatotoxicity, which is a serious toxicity of this drug.
How serious is the interaction between Gemfibrozil and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin closely. Reduce the pexidartinib dose according to labeling if a UGT inhibitor is required.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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