Drug interactions
Gemfibrozil + Terbinafine
Severity: Minor
Gemfibrozil and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits CYP2C9 and could theoretically raise terbinafine levels. Terbinafine has multiple elimination pathways, so a clinically important change is unlikely.
What this interaction means in plain words
Gemfibrozil and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gemfibrozil belongs to Cardiovascular; Terbinafine belongs to Anti Fungals.
Why it happens
Gemfibrozil inhibits CYP2C9, one of several enzymes involved in terbinafine metabolism.
What to do
No dose adjustment is needed; monitor for terbinafine adverse effects such as gastrointestinal upset and liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Terbinafine?
MediHelp rates the interaction as minor. Gemfibrozil and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil inhibits CYP2C9 and could theoretically raise terbinafine levels. Terbinafine has multiple elimination pathways, so a clinically important change is unlikely.
How serious is the interaction between Gemfibrozil and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for terbinafine adverse effects such as gastrointestinal upset and liver enzyme elevation.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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