Drug interactions
Gemfibrozil + Tolazamide
Severity: Moderate
Gemfibrozil and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may enhance the hypoglycemic effect of tolazamide. Displacement from plasma proteins and additive glucose lowering are the proposed explanations. Patients with low albumin or poor oral intake are at greater risk.
What this interaction means in plain words
Gemfibrozil and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Possible protein-binding displacement and additive glucose lowering.
What to do
Monitor blood glucose when starting or stopping gemfibrozil. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Gemfibrozil with Tolazamide?
MediHelp rates the interaction as moderate. Gemfibrozil and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may enhance the hypoglycemic effect of tolazamide. Displacement from plasma proteins and additive glucose lowering are the proposed explanations. Patients with low albumin or poor oral intake are at greater risk.
How serious is the interaction between Gemfibrozil and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping gemfibrozil. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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