Drug interactions
Gemfibrozil + Treprostinil
Severity: Moderate
Gemfibrozil and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil increases treprostinil exposure. This may increase prostacyclin-related effects such as headache, flushing, hypotension and jaw pain.
What this interaction means in plain words
Gemfibrozil and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibits CYP2C8, reducing treprostinil metabolism.
What to do
Monitor for treprostinil adverse effects and reduce the dose if poorly tolerated. Re-titrate if gemfibrozil is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Treprostinil
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Treprostinil?
MediHelp rates the interaction as moderate. Gemfibrozil and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil increases treprostinil exposure. This may increase prostacyclin-related effects such as headache, flushing, hypotension and jaw pain.
How serious is the interaction between Gemfibrozil and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treprostinil adverse effects and reduce the dose if poorly tolerated. Re-titrate if gemfibrozil is stopped.
What other medicines interact with Treprostinil?
MediHelp also lists interactions of Treprostinil with, for example, Aldesleukin, Alfuzosin, Amlodipine-atorvastatin. The full list is on the Treprostinil page.
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