Drug interactions
Gemfibrozil + Warfarin
Severity: Moderate
Gemfibrozil and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil can enhance the anticoagulant effect of warfarin, raising INR and the risk of bleeding. A warfarin dose reduction is often needed.
What this interaction means in plain words
Gemfibrozil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9-mediated warfarin metabolism, with possible protein-binding displacement.
What to do
Monitor INR closely on starting or stopping gemfibrozil and reduce warfarin dose as indicated. Consider a different lipid-lowering agent if control is difficult.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Warfarin?
MediHelp rates the interaction as moderate. Gemfibrozil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil can enhance the anticoagulant effect of warfarin, raising INR and the risk of bleeding. A warfarin dose reduction is often needed.
How serious is the interaction between Gemfibrozil and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely on starting or stopping gemfibrozil and reduce warfarin dose as indicated. Consider a different lipid-lowering agent if control is difficult.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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