Drug interactions
Gemifloxacin + Hydroxyzine
Severity: Moderate
Gemifloxacin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and hydroxyzine has been linked to torsades de pointes. Combined use increases arrhythmia risk, especially in older patients or those with cardiac disease.
What this interaction means in plain words
Gemifloxacin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Hydroxyzine belongs to Respiratory.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Use an alternative antihistamine or antibiotic where possible. If combined, correct electrolytes and monitor the ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Gemifloxacin with Hydroxyzine?
MediHelp rates the interaction as moderate. Gemifloxacin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and hydroxyzine has been linked to torsades de pointes. Combined use increases arrhythmia risk, especially in older patients or those with cardiac disease.
How serious is the interaction between Gemifloxacin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antihistamine or antibiotic where possible. If combined, correct electrolytes and monitor the ECG in high-risk patients.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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