Drug interactions
Gemifloxacin + Macimorelin
Severity: Major
Gemifloxacin and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval and gemifloxacin has a similar effect. Coadministration may increase the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Gemifloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Postpone macimorelin testing until gemifloxacin has been stopped and cleared. Use an alternative if the test cannot wait.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Gemifloxacin with Macimorelin?
MediHelp rates the interaction as major. Gemifloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and gemifloxacin has a similar effect. Coadministration may increase the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Gemifloxacin and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone macimorelin testing until gemifloxacin has been stopped and cleared. Use an alternative if the test cannot wait.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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