Drug interactions
Gemifloxacin + Osilodrostat
Severity: Moderate
Gemifloxacin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and osilodrostat labeling advises caution with other QT-prolonging drugs. Hypokalemia from cortisol suppression may add to the risk of torsades de pointes.
What this interaction means in plain words
Gemifloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium before and during combined use. Consider an alternative antibiotic with less QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Gemifloxacin with Osilodrostat?
MediHelp rates the interaction as moderate. Gemifloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and osilodrostat labeling advises caution with other QT-prolonging drugs. Hypokalemia from cortisol suppression may add to the risk of torsades de pointes.
How serious is the interaction between Gemifloxacin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during combined use. Consider an alternative antibiotic with less QT effect.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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