Drug interactions
Gemifloxacin + Osimertinib
Severity: Moderate
Gemifloxacin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, as does gemifloxacin. Combined use may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Gemifloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform periodic ECG and electrolyte monitoring and correct abnormalities. Prefer a non-QT-prolonging antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Gemifloxacin with Osimertinib?
MediHelp rates the interaction as moderate. Gemifloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, as does gemifloxacin. Combined use may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Gemifloxacin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring and correct abnormalities. Prefer a non-QT-prolonging antibiotic when possible.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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