Drug interactions
Gemifloxacin + Perphenazine
Severity: Moderate
Gemifloxacin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can prolong the QT interval, and gemifloxacin shares this property. Using them together may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Gemifloxacin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Perphenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel blockade.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before combining. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Gemifloxacin with Perphenazine?
MediHelp rates the interaction as moderate. Gemifloxacin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can prolong the QT interval, and gemifloxacin shares this property. Using them together may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Gemifloxacin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before combining. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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