Drug interactions
Gemifloxacin + Piroxicam
Severity: Moderate
Gemifloxacin and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the seizure-provoking potential of fluoroquinolones, especially in patients with epilepsy, CNS disease or at higher doses. The overall risk is small but is clinically relevant in predisposed individuals.
What this interaction means in plain words
Gemifloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptors and NSAIDs may potentiate this effect, lowering seizure threshold.
What to do
Avoid the combination in patients with seizure disorders or other seizure risk factors. Otherwise use the lowest effective doses and counsel patients to report tremor, confusion or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gemifloxacin and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Piroxicam?
MediHelp rates the interaction as moderate. Gemifloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the seizure-provoking potential of fluoroquinolones, especially in patients with epilepsy, CNS disease or at higher doses. The overall risk is small but is clinically relevant in predisposed individuals.
How serious is the interaction between Gemifloxacin and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other seizure risk factors. Otherwise use the lowest effective doses and counsel patients to report tremor, confusion or seizures.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
