Drug interactions
Gemifloxacin + Solifenacin
Severity: Moderate
Gemifloxacin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin can prolong the QT interval, and solifenacin may add to this effect at higher exposures. The combination may raise arrhythmia risk, particularly with other risk factors.
What this interaction means in plain words
Gemifloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Consider an alternative antibiotic in patients with QT risk factors. If used, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Solifenacin?
MediHelp rates the interaction as moderate. Gemifloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin can prolong the QT interval, and solifenacin may add to this effect at higher exposures. The combination may raise arrhythmia risk, particularly with other risk factors.
How serious is the interaction between Gemifloxacin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors. If used, correct electrolytes and monitor the ECG.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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