Drug interactions
Gemifloxacin + Vorinostat
Severity: Moderate
Gemifloxacin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, as has gemifloxacin. Using both may increase the chance of torsades de pointes, particularly with electrolyte disturbances common in cancer patients.
What this interaction means in plain words
Gemifloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Monitor the ECG and keep potassium and magnesium in the normal range. Consider an alternative antibiotic if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Gemifloxacin with Vorinostat?
MediHelp rates the interaction as moderate. Gemifloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, as has gemifloxacin. Using both may increase the chance of torsades de pointes, particularly with electrolyte disturbances common in cancer patients.
How serious is the interaction between Gemifloxacin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and keep potassium and magnesium in the normal range. Consider an alternative antibiotic if the QTc lengthens.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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