Drug interactions
Gentamicin + Hydrochlorothiazide-lisinopril
Severity: Moderate
Gentamicin and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide-related electrolyte loss and aminoglycoside nephrotoxicity may impair renal function, and the ACE inhibitor and volume depletion add further risk. Hypokalemia and hypomagnesemia can also occur with gentamicin and may worsen with the diuretic.
What this interaction means in plain words
Gentamicin and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Aminoglycoside tubular toxicity combined with diuretic-induced volume depletion and ACE inhibitor effects on glomerular filtration increases kidney injury risk.
What to do
Monitor serum creatinine, potassium and magnesium and gentamicin levels. Consider holding the diuretic and ACE inhibitor if volume depletion or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Gentamicin and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide-related electrolyte loss and aminoglycoside nephrotoxicity may impair renal function, and the ACE inhibitor and volume depletion add further risk. Hypokalemia and hypomagnesemia can also occur with gentamicin and may worsen with the diuretic.
How serious is the interaction between Gentamicin and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium and gentamicin levels. Consider holding the diuretic and ACE inhibitor if volume depletion or renal decline occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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