Drug interactions
Gentamicin + Lornoxicam
Severity: Moderate
Gentamicin and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis and renal blood flow, which can impair gentamicin clearance and raise its serum levels. This increases the risk of nephrotoxicity and possibly ototoxicity.
What this interaction means in plain words
Gentamicin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID-mediated reduction of renal perfusion and glomerular filtration decreases aminoglycoside elimination and adds to nephrotoxicity.
What to do
Avoid the combination where possible, or monitor creatinine and gentamicin trough levels and keep the patient hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Gentamicin with Lornoxicam?
MediHelp rates the interaction as moderate. Gentamicin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin synthesis and renal blood flow, which can impair gentamicin clearance and raise its serum levels. This increases the risk of nephrotoxicity and possibly ototoxicity.
How serious is the interaction between Gentamicin and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor creatinine and gentamicin trough levels and keep the patient hydrated.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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