Drug interactions
Gentamicin + Nabumetone
Severity: Moderate
Gentamicin and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of aminoglycosides and, together with gentamicin, increase the risk of nephrotoxicity. Higher gentamicin concentrations raise the risk of kidney injury and ototoxicity.
What this interaction means in plain words
Gentamicin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and glomerular filtration, decreasing gentamicin elimination and adding to its tubular toxicity.
What to do
Monitor serum creatinine and gentamicin trough levels and adjust the dose accordingly. Avoid nabumetone in patients with renal impairment or dehydration receiving gentamicin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Nabumetone?
MediHelp rates the interaction as moderate. Gentamicin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of aminoglycosides and, together with gentamicin, increase the risk of nephrotoxicity. Higher gentamicin concentrations raise the risk of kidney injury and ototoxicity.
How serious is the interaction between Gentamicin and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels and adjust the dose accordingly. Avoid nabumetone in patients with renal impairment or dehydration receiving gentamicin.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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