Drug interactions
Gentamicin + Oxaliplatin
Severity: Moderate
Gentamicin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney and gentamicin is also ototoxic. Although oxaliplatin is less nephrotoxic than cisplatin, combined use may add to renal damage and reduced clearance of gentamicin.
What this interaction means in plain words
Gentamicin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity, with possible additive ototoxicity, through tubular injury.
What to do
Monitor serum creatinine and gentamicin levels, and maintain hydration. Choose a non-nephrotoxic antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Gentamicin with Oxaliplatin?
MediHelp rates the interaction as moderate. Gentamicin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney and gentamicin is also ototoxic. Although oxaliplatin is less nephrotoxic than cisplatin, combined use may add to renal damage and reduced clearance of gentamicin.
How serious is the interaction between Gentamicin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, and maintain hydration. Choose a non-nephrotoxic antibiotic if possible.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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