Drug interactions
Gepirone + Naratriptan
Severity: Moderate
Gepirone and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a 5-HT1A agonist antidepressant, and serotonin syndrome is a labeled concern with other serotonergic drugs. Triptan use with serotonergic antidepressants has been associated with rare serotonin syndrome reports. The risk is likely low but clinically important.
What this interaction means in plain words
Gepirone and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic pharmacodynamic effects at 5-HT receptors.
What to do
Counsel the patient on serotonin syndrome symptoms and monitor, especially during initiation or dose increases. Stop the serotonergic agent if syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gepirone and Naratriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Naratriptan?
MediHelp rates the interaction as moderate. Gepirone and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a 5-HT1A agonist antidepressant, and serotonin syndrome is a labeled concern with other serotonergic drugs. Triptan use with serotonergic antidepressants has been associated with rare serotonin syndrome reports. The risk is likely low but clinically important.
How serious is the interaction between Gepirone and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on serotonin syndrome symptoms and monitor, especially during initiation or dose increases. Stop the serotonergic agent if syndrome occurs.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
