Drug interactions
Gepirone + Tranylcypromine
Severity: Contraindicated
Gepirone and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a 5-HT1A agonist antidepressant, and combining it with an MAOI can produce serotonin syndrome. Labeling contraindicates use with MAOIs or within 14 days of stopping one.
What this interaction means in plain words
Gepirone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gepirone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive serotonergic stimulation with inhibition of serotonin metabolism by MAO.
What to do
Do not coadminister. Allow at least 14 days after stopping tranylcypromine before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Gepirone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gepirone is a 5-HT1A agonist antidepressant, and combining it with an MAOI can produce serotonin syndrome. Labeling contraindicates use with MAOIs or within 14 days of stopping one.
How serious is the interaction between Gepirone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping tranylcypromine before starting gepirone, and at least 14 days after stopping gepirone before starting an MAOI.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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