Drug interactions
Gepirone + Verapamil
Severity: Moderate
Gepirone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil increases gepirone exposure through CYP3A4 inhibition. This raises the risk of dizziness, nausea, sedation and QT prolongation.
What this interaction means in plain words
Gepirone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition decreases gepirone clearance.
What to do
Reduce the gepirone dose by 50% when used with verapamil, and monitor for adverse effects including ECG changes where indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Verapamil?
MediHelp rates the interaction as moderate. Gepirone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil increases gepirone exposure through CYP3A4 inhibition. This raises the risk of dizziness, nausea, sedation and QT prolongation.
How serious is the interaction between Gepirone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the gepirone dose by 50% when used with verapamil, and monitor for adverse effects including ECG changes where indicated.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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