Drug interactions
Gilteritinib + Granisetron
Severity: Major
Gilteritinib and Granisetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is labeled for QT prolongation, and granisetron can add a small further effect. The combination raises the risk of serious ventricular arrhythmia, particularly with electrolyte abnormalities.
What this interaction means in plain words
Gilteritinib and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and correct potassium and magnesium. Prefer a non-QT-prolonging antiemetic where possible, and interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Granisetron?
MediHelp rates the interaction as major. Gilteritinib and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib is labeled for QT prolongation, and granisetron can add a small further effect. The combination raises the risk of serious ventricular arrhythmia, particularly with electrolyte abnormalities.
How serious is the interaction between Gilteritinib and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium. Prefer a non-QT-prolonging antiemetic where possible, and interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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