Drug interactions
Gilteritinib + Indacaterol-glycopyrronium
Severity: Moderate
Gilteritinib and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and indacaterol can add to this through beta-agonist cardiac effects and hypokalaemia. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Gilteritinib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarisation and beta-agonist related hypokalaemia.
What to do
Obtain baseline and periodic ECGs and keep potassium and magnesium in range. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Gilteritinib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and indacaterol can add to this through beta-agonist cardiac effects and hypokalaemia. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Gilteritinib and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and keep potassium and magnesium in range. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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