Drug interactions
Gilteritinib + Itraconazole
Severity: Major
Gilteritinib and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases gilteritinib exposure through CYP3A4 and P-gp inhibition, and both drugs prolong QT. This raises the risk of differentiation syndrome, hepatotoxicity and arrhythmia.
What this interaction means in plain words
Gilteritinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 and P-gp inhibition decreases gilteritinib clearance, with additive QT prolongation.
What to do
Use an alternative antifungal where possible. If combined, monitor ECG, electrolytes, liver tests and for gilteritinib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Itraconazole?
MediHelp rates the interaction as major. Gilteritinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases gilteritinib exposure through CYP3A4 and P-gp inhibition, and both drugs prolong QT. This raises the risk of differentiation syndrome, hepatotoxicity and arrhythmia.
How serious is the interaction between Gilteritinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal where possible. If combined, monitor ECG, electrolytes, liver tests and for gilteritinib adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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