Drug interactions
Gilteritinib + Loperamide
Severity: Moderate
Gilteritinib and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and loperamide at high doses has caused QT prolongation and torsades de pointes. Using them together increases arrhythmia risk, particularly in patients with electrolyte disturbances.
What this interaction means in plain words
Gilteritinib and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive hERG-mediated QT interval prolongation.
What to do
Use loperamide only at labeled doses, correct potassium and magnesium, and monitor ECG as required for gilteritinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Loperamide?
MediHelp rates the interaction as moderate. Gilteritinib and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and loperamide at high doses has caused QT prolongation and torsades de pointes. Using them together increases arrhythmia risk, particularly in patients with electrolyte disturbances.
How serious is the interaction between Gilteritinib and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide only at labeled doses, correct potassium and magnesium, and monitor ECG as required for gilteritinib therapy.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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