Drug interactions
Gilteritinib + Rosuvastatin
Severity: Moderate
Gilteritinib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib may inhibit BCRP and could raise rosuvastatin exposure. Higher levels increase the risk of myopathy and, rarely, rhabdomyolysis.
What this interaction means in plain words
Gilteritinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of BCRP by gilteritinib may increase rosuvastatin absorption and reduce its elimination.
What to do
Monitor for muscle pain, weakness and CK elevation. Use the lowest effective rosuvastatin dose or temporarily hold it if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Gilteritinib with Rosuvastatin?
MediHelp rates the interaction as moderate. Gilteritinib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib may inhibit BCRP and could raise rosuvastatin exposure. Higher levels increase the risk of myopathy and, rarely, rhabdomyolysis.
How serious is the interaction between Gilteritinib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation. Use the lowest effective rosuvastatin dose or temporarily hold it if symptoms develop.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
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