Drug interactions
Gilteritinib + Tacrolimus
Severity: Moderate
Gilteritinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib and tacrolimus can both prolong the QT interval, so the combination may increase the risk of torsades de pointes. Patients with acute myeloid leukemia often have additional risk factors such as electrolyte loss and concomitant azoles or antiemetics.
What this interaction means in plain words
Gilteritinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Perform ECG monitoring at baseline and periodically during therapy, and keep potassium and magnesium within normal range. Interrupt or reduce gilteritinib if QTc becomes markedly prolonged, per its labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Tacrolimus?
MediHelp rates the interaction as moderate. Gilteritinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib and tacrolimus can both prolong the QT interval, so the combination may increase the risk of torsades de pointes. Patients with acute myeloid leukemia often have additional risk factors such as electrolyte loss and concomitant azoles or antiemetics.
How serious is the interaction between Gilteritinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and periodically during therapy, and keep potassium and magnesium within normal range. Interrupt or reduce gilteritinib if QTc becomes markedly prolonged, per its labeling.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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