Drug interactions
Gilteritinib + Voriconazole
Severity: Major
Gilteritinib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases gilteritinib exposure through CYP3A4 inhibition, raising the risk of toxicity such as differentiation syndrome and hepatotoxicity. Both agents also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Gilteritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gilteritinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by voriconazole reduces gilteritinib clearance, plus additive QT prolongation.
What to do
Prefer an antifungal that is not a strong CYP3A4 inhibitor. If unavoidable, monitor ECG, electrolytes and adverse effects, and interrupt or reduce gilteritinib for serious toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Voriconazole?
MediHelp rates the interaction as major. Gilteritinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases gilteritinib exposure through CYP3A4 inhibition, raising the risk of toxicity such as differentiation syndrome and hepatotoxicity. Both agents also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Gilteritinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal that is not a strong CYP3A4 inhibitor. If unavoidable, monitor ECG, electrolytes and adverse effects, and interrupt or reduce gilteritinib for serious toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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