Drug interactions
Givinostat + Leuprolide
Severity: Moderate
Givinostat and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and leuprolide may add to this effect. Together they raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Givinostat and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain ECGs at initiation and during combined use. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Leuprolide?
MediHelp rates the interaction as moderate. Givinostat and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and leuprolide may add to this effect. Together they raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Givinostat and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during combined use. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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