Drug interactions
Givinostat + Propofol
Severity: Minor
Givinostat and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, whereas propofol has little consistent QT-prolonging effect. Clinically significant additive risk is possible mainly in patients with other risk factors.
What this interaction means in plain words
Givinostat and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Propofol belongs to Central Nervous System.
Why it happens
Givinostat prolongs QT; propofol's contribution to repolarization delay is minimal and not firmly established.
What to do
Check ECG and correct potassium and magnesium before sedation in at-risk patients. No routine change to propofol dosing is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Propofol?
MediHelp rates the interaction as minor. Givinostat and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat can prolong the QT interval, whereas propofol has little consistent QT-prolonging effect. Clinically significant additive risk is possible mainly in patients with other risk factors.
How serious is the interaction between Givinostat and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before sedation in at-risk patients. No routine change to propofol dosing is needed.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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