Drug interactions
Amitriptyline + Givosiran
Severity: Moderate
Amitriptyline and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can inhibit CYP2D6 and thereby raise levels of CYP2D6 substrates such as amitriptyline. Higher exposure can increase anticholinergic, sedative and cardiac toxicity.
What this interaction means in plain words
Amitriptyline and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing amitriptyline metabolism.
What to do
Consider a lower amitriptyline dose and monitor for tricyclic toxicity and ECG changes while on givosiran.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Amitriptyline with Givosiran?
MediHelp rates the interaction as moderate. Amitriptyline and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can inhibit CYP2D6 and thereby raise levels of CYP2D6 substrates such as amitriptyline. Higher exposure can increase anticholinergic, sedative and cardiac toxicity.
How serious is the interaction between Amitriptyline and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower amitriptyline dose and monitor for tricyclic toxicity and ECG changes while on givosiran.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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