Drug interactions
Givosiran + Propranolol
Severity: Moderate
Givosiran and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to CYP1A2 and CYP2D6 substrates, both pathways of propranolol metabolism. Propranolol levels and beta-blocker effects may increase.
What this interaction means in plain words
Givosiran and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Propranolol belongs to Cardiovascular.
Why it happens
Givosiran reduces CYP1A2 and CYP2D6 activity, decreasing propranolol clearance.
What to do
Monitor heart rate and blood pressure after starting givosiran. Reduce the propranolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Propranolol?
MediHelp rates the interaction as moderate. Givosiran and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to CYP1A2 and CYP2D6 substrates, both pathways of propranolol metabolism. Propranolol levels and beta-blocker effects may increase.
How serious is the interaction between Givosiran and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting givosiran. Reduce the propranolol dose if bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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