Drug interactions
Givosiran + Venlafaxine
Severity: Moderate
Givosiran and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6, which converts venlafaxine to its active metabolite. Parent venlafaxine levels may rise, which can increase dose-related adverse effects such as hypertension and nausea.
What this interaction means in plain words
Givosiran and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 metabolism of venlafaxine.
What to do
Monitor blood pressure and tolerability and consider a lower venlafaxine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Venlafaxine?
MediHelp rates the interaction as moderate. Givosiran and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can moderately inhibit CYP2D6, which converts venlafaxine to its active metabolite. Parent venlafaxine levels may rise, which can increase dose-related adverse effects such as hypertension and nausea.
How serious is the interaction between Givosiran and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability and consider a lower venlafaxine dose if adverse effects appear.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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