Drug interactions
Glasdegib + Leuprolide
Severity: Moderate
Glasdegib and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib is labeled for QTc prolongation, and leuprolide may add to this through androgen deprivation effects. The risk of ventricular arrhythmia may be higher with electrolyte abnormalities.
What this interaction means in plain words
Glasdegib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes more often during co-treatment, and correct abnormalities. Interrupt or reduce glasdegib per labeling if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Leuprolide?
MediHelp rates the interaction as moderate. Glasdegib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib is labeled for QTc prolongation, and leuprolide may add to this through androgen deprivation effects. The risk of ventricular arrhythmia may be higher with electrolyte abnormalities.
How serious is the interaction between Glasdegib and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes more often during co-treatment, and correct abnormalities. Interrupt or reduce glasdegib per labeling if QTc rises significantly.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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