Drug interactions
Glasdegib + Posaconazole
Severity: Major
Glasdegib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase glasdegib exposure by inhibiting its CYP3A4-mediated metabolism. Glasdegib is associated with QT prolongation, and higher exposure along with posaconazole's own QT effect raises the risk of arrhythmia.
What this interaction means in plain words
Glasdegib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glasdegib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces glasdegib clearance, with additive QTc prolongation.
What to do
Prefer an antifungal that is not a strong CYP3A4 inhibitor. If coadministered, monitor ECG and electrolytes and watch for glasdegib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glasdegib and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Posaconazole?
MediHelp rates the interaction as major. Glasdegib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can increase glasdegib exposure by inhibiting its CYP3A4-mediated metabolism. Glasdegib is associated with QT prolongation, and higher exposure along with posaconazole's own QT effect raises the risk of arrhythmia.
How serious is the interaction between Glasdegib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal that is not a strong CYP3A4 inhibitor. If coadministered, monitor ECG and electrolytes and watch for glasdegib adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
